| Fidelity | 2.88M | $43M | −$711.6K | Added$39M |
| Caligan Partners LP | 1.64M | $24.4M | −$2.85M | Added$8.4M |
| BVF INC/IL | 1.63M | $24.4M | −$4.38M | Cut−$233.1K |
| Avoro Capital Advisors LLC | 1.41M | $21.1M | — | New |
| Affinity Asset Advisors, LLC | 1.34M | $20M | −$3.39M | Added$931.6K |
| Nantahala Capital Management, LLC | 1.24M | $18.4M | −$3.99M | Cut−$3.99M |
| UBS Group AG | 1.14M | $17M | −$1.54M | Added$8.37M |
| Point72 Asset Management, L.P. | 916.1K | $13.7M | −$2.03M | Added$2.28M |
| FARALLON CAPITAL MANAGEMENT LLC | 916K | $13.7M | — | New |
| RTW INVESTMENTS, LP | 857K | $12.8M | — | New |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 854K | $12.8M | −$1.78M | Added$2.76M |
| MILLENNIUM MANAGEMENT LLC | 835.5K | $12.5M | −$2.13M | Added$488.6K |
| TCG Crossover Management, LLC | 738.4K | $11M | −$1.56M | Added$2.25M |
| Balyasny Asset Management L.P. | 731.6K | $10.9M | −$1.42M | Added$2.94M |
| VANGUARD CAPITAL MANAGEMENT LLC | 719.7K | $10.7M | — | Held |
| RA CAPITAL MANAGEMENT, L.P. | 663K | $9.9M | −$2.14M | Cut−$2.14M |
| BANK OF AMERICA CORP /DE/ | 643K | $9.6M | −$2.01M | Cut−$1.68M |
| Seven Fleet Capital Management LP | 573.9K | $8.57M | −$204.6K | Added$7.42M |
| Commodore Capital LP | 483K | $7.21M | −$1.56M | Cut−$1.56M |
| ORBIMED ADVISORS LLC | 475.2K | $7.09M | −$1.53M | Cut−$14.5M |
| JENNISON ASSOCIATES LLC | 470.8K | $7.03M | −$1.52M | Cut−$1.61M |
| Caption Management, LLC | 455K | $6.79M | −$170K | Added$5.84M |
| Soleus Capital Management, L.P. | 442K | $6.6M | −$1.43M | Cut−$1.43M |
| BNP PARIBAS FINANCIAL MARKETS | 422.8K | $6.31M | −$638.7K | Added$2.72M |
| KENNEDY CAPITAL MANAGEMENT LLC | 388K | $5.79M | — | New |
| DV Trading LLC | 360.1K | $5.38M | — | New |
| BlackRock, Inc. | 327.1K | $4.88M | −$935.3K | Cut−$375.3K |
| BOOTHBAY FUND MANAGEMENT, LLC | 324.3K | $4.84M | −$652.9K | Added$1.17M |
| Logos Global Management LP | 300K | $4.48M | — | New |
| Boxer Capital Management, LLC | 300K | $4.48M | −$888.3K | Cut−$515K |
| Pivotal bioVenture Partners Investment Advisor LLC | 295.9K | $4.42M | — | New |
| Citadel | 193.7K | $2.89M | −$625.8K | Cut−$4.73M |
| NAN FUNG TRINITY (HK) LTD | 189K | $2.82M | −$610.5K | Cut−$610.5K |
| Velan Capital Investment Management LP | 185.1K | $2.76M | −$597.9K | Cut−$2.02M |
| JPMORGAN CHASE & CO | 194.4K | $2.71M | −$187.9K | Added$1.9M |
| Qube Research & Technologies Ltd | 174.5K | $2.61M | −$208.2K | Added$1.43M |
| JANE STREET GROUP, LLC | 173.3K | $2.59M | −$559.8K | Cut−$660.3K |
| AMERIPRISE FINANCIAL INC | 172.1K | $2.57M | −$556K | Cut−$1.39M |
| Aberdeen Group plc | 171.7K | $2.56M | −$308.2K | Added$830.2K |
| GEODE CAPITAL MANAGEMENT, LLC | 169.9K | $2.54M | −$536.3K | Cut−$480.5K |
| MORGAN STANLEY | 161.4K | $2.41M | −$521.3K | Cut−$2.4M |
| Hudson Bay Capital Management LP | 161.1K | $2.41M | −$54.2K | Added$2.1M |
| Exome Asset Management LLC | 159.3K | $2.38M | — | New |
| Moody Aldrich Partners LLC | 159.3K | $2.38M | −$430.3K | Cut−$40.8K |
| DEUTSCHE BANK AG\ | 150K | $2.24M | −$484.5K | Cut−$484.5K |
| PERCEPTIVE ADVISORS LLC | 139.7K | $2.09M | −$451.1K | Cut−$451.1K |
| STEMPOINT CAPITAL LP | 134.7K | $2.01M | −$435.2K | Cut−$449.9K |
| MARSHALL WACE, LLP | 129.1K | $1.93M | −$417.1K | Cut−$7.29M |
| XTX Topco Ltd | 126.7K | $1.89M | −$130.7K | Added$1.16M |
| Quadrature Capital Ltd | 125.2K | $1.87M | −$171.3K | Added$905.9K |
| GREAT POINT PARTNERS LLC | 124.7K | $1.86M | −$402.7K | Cut−$402.7K |
| Renaissance Technologies | 120.1K | $1.79M | −$59.1K | Added$1.46M |
| VANGUARD FIDUCIARY TRUST CO | 86.4K | $1.29M | — | Held |
| Squarepoint Ops LLC | 81.3K | $1.21M | −$132K | Added$471.7K |
| Rosalind Advisors, Inc. | 75K | $1.12M | — | New |
| State Street | 71.7K | $1.07M | −$231.4K | Cut−$369.5K |
| TWO SIGMA INVESTMENTS, LP | 64.4K | $961.9K | −$208.1K | Cut−$1.73M |
| ACUTA CAPITAL PARTNERS, LLC | 60.8K | $907.9K | — | New |
| GOLDMAN SACHS GROUP INC | 60.1K | $897.4K | −$194.1K | Cut−$288.7K |
| HighVista Strategies LLC | 58.6K | $875.2K | −$189.3K | Cut−$861.4K |
| SEI INVESTMENTS CO | 56.9K | $848.8K | — | New |
| 683 Capital Management, LLC | 56.9K | $848.8K | −$183.6K | Cut−$183.6K |
| TD Asset Management Inc | 51.4K | $767.5K | — | New |
| Man Group plc | 46.6K | $695K | — | New |
| DIMENSIONAL FUND ADVISORS LP | 40.8K | $607.3K | — | New |
| PRELUDE CAPITAL MANAGEMENT, LLC | 35.1K | $524K | — | New |
| NORTHERN TRUST CORP | 30.6K | $456.2K | −$98.7K | Cut−$128.6K |
| EntryPoint Capital, LLC | 30K | $448.5K | — | New |
| Aquatic Capital Management LLC | 29.7K | $443.6K | — | New |
| Artia Global Partners LP | 29K | $432.5K | −$93.6K | Cut−$322.4K |
| GLENMEDE TRUST CO NA | 25.7K | $384.1K | −$66.1K | Added$12.8K |
| ENVESTNET ASSET MANAGEMENT INC | 20K | $298.5K | −$51.8K | Added$7.27K |
| Brevan Howard Capital Management LP | 19.3K | $288.5K | — | New |
| ExodusPoint Capital Management, LP | 17.8K | $265K | −$57.3K | Cut−$320.9K |
| Susquehanna Portfolio Strategies, LLC | 17.2K | $257.2K | — | New |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 15.6K | $233.5K | — | New |
| BARCLAYS PLC | 14.6K | $218.6K | −$47.3K | Cut−$1.7M |
| Jump Financial, LLC | 12.8K | $191.3K | −$41.4K | Cut−$46.5K |
| OMERS ADMINISTRATION Corp | 11.8K | $176.2K | −$38.1K | Cut−$179.8K |
| AlphaCentric Advisors LLC | 11.7K | $174.2K | — | New |
| Shay Capital LLC | 10.2K | $151.8K | — | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10K | $149.3K | — | New |
| Persistent Asset Partners Ltd | 7.92K | $118.2K | −$25.6K | Cut−$155.8K |
| Vanguard Global Advisers, LLC | 5.61K | $83.7K | — | Held |
| US BANCORP \DE\ | 3.39K | $50.6K | −$8.83K | Added$937 |
| T. Rowe Price Investment Management, Inc. | 2.16M | $32.3K | — | New |
| PFS Partners, LLC | 2K | $29.9K | −$6.46K | Cut−$6.46K |
| ROYAL BANK OF CANADA | 216 | $2K | — | New |
| Farther Finance Advisors, LLC | 75 | $1.25K | — | New |
| Fortitude Family Office, LLC | 63 | $941 | — | New |
| HRT FINANCIAL LP | 48.1K | $718 | — | New |
| EverSource Wealth Advisors, LLC | 35 | $523 | — | New |
| Silver Grove Financial Group, Inc. | 1 | $15 | — | New |
| Parallel Advisors, LLC | 1 | $15 | −$3 | Cut−$3 |
| Key Financial Inc | 1 | $15 | −$3 | Cut−$3 |
| Activest Wealth Management | 1 | $15 | −$3 | Cut−$3 |
| OSAIC HOLDINGS, INC. | 1 | $14 | −$4 | Cut−$4 |