| RA CAPITAL MANAGEMENT, L.P. | 7.26M | $144.3M | $21.3M | Added$27.3M |
| Siren, L.L.C. | 5.8M | $115.4M | $16M | Added$27.6M |
| Vestal Point Capital, LP | 5.42M | $107.9M | $10.9M | Added$47.7M |
| Deep Track Capital, LP | 4.06M | $80.8M | $8M | Added$36.8M |
| JANUS HENDERSON GROUP PLC | 3.34M | $66.4M | $8.1M | Added$21.9M |
| RED TREE MANAGEMENT, LLC | 3.17M | $63.1M | $9.7M | Added$9.7M |
| TPG GP A, LLC | 3.01M | $59.9M | $9.21M | Added$9.21M |
| BlackRock, Inc. | 2.84M | $56.6M | $7.74M | Added$14M |
| Omega Fund Management, LLC | 2.39M | $47.6M | $6.75M | Added$10.5M |
| Royalty Pharma Sub-Manager, LLC | 2.39M | $46.7M | −$21.2M | Added$823.4K |
| Fidelity | 2.1M | $41.8M | $6.43M | Cut−$14.5M |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.77M | $35.3M | — | Held |
| Citadel | 1.66M | $33M | $2.36M | Added$20M |
| FRANKLIN RESOURCES INC | 1.62M | $32.3M | $4.96M | Added$4.99M |
| State Street | 1.42M | $28.2M | $4.34M | Added$469.9K |
| Jones Hill Capital LP | 1.26M | $25.1M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 830.9K | $16.5M | $2.48M | Added$2.87M |
| FIL Ltd | 679.9K | $13.5M | $2.08M | Added$757.9K |
| ORBIMED ADVISORS LLC | 667.3K | $13.3M | $639.8K | Added$9.75M |
| ACORN CAPITAL ADVISORS, LLC | 643.4K | $12.8M | $1.97M | Added$1.97M |
| Aisling Capital Management LP | 568.9K | $11.3M | $1.74M | Added$1.74M |
| GOLDMAN SACHS GROUP INC | 559K | $11.1M | $1.69M | Added$1.82M |
| Palo Alto Investors LP | 550.4K | $10.9M | $913.6K | Added$5.92M |
| Rock Springs Capital Management LP | 489.1K | $9.73M | $1.31M | Added$2.51M |
| NAN FUNG TRINITY (HK) LTD | 427.9K | $8.51M | $1.14M | Added$2.24M |
| DAFNA Capital Management LLC | 421.7K | $8.39M | $800.4K | Added$3.99M |
| MORGAN STANLEY | 421.2K | $8.38M | $334.9K | Added$6.54M |
| Ensign Peak Advisors, Inc | 401.4K | $7.98M | $1.23M | Added$1.23M |
| BANK OF AMERICA CORP /DE/ | 328K | $6.52M | $1M | Added$874.2K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 290.9K | $5.79M | — | Held |
| Clearbridge Investments, LLC | 289.2K | $5.75M | $885K | Added$724.4K |
| D. E. Shaw & Co., Inc. | 276.9K | $5.51M | $417.8K | Added$3.21M |
| TD Asset Management Inc | 269.7K | $5.36M | $748.6K | Added$1.25M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 264K | $5.25M | $807.8K | Added$670.5K |
| NORTHERN TRUST CORP | 255.6K | $5.08M | $725.5K | Added$1.09M |
| Candriam S.C.A. | 238.8K | $4.75M | — | New |
| Hudson Bay Capital Management LP | 233.7K | $4.65M | $459K | Added$2.12M |
| Woodline Partners LP | 232.7K | $4.63M | $712K | Added$712K |
| VANGUARD FIDUCIARY TRUST CO | 216.8K | $4.31M | — | Held |
| UBS Group AG | 179.5K | $3.57M | $549.2K | Added$335.5K |
| JPMORGAN CHASE & CO | 177.4K | $3.38M | $37.2K | Added$3.09M |
| MILLENNIUM MANAGEMENT LLC | 156.7K | $3.12M | $479.5K | Cut−$4.2M |
| DEUTSCHE BANK AG\ | 131.7K | $2.62M | $393.6K | Added$453.9K |
| Atle Fund Management AB | 1.17M | $2.32M | −$1.65M | Added$441K |
| Napean Trading & Investment Co (Singapore) PTE Ltd | 113.8K | $2.26M | $348.2K | Added$348.2K |
| DIMENSIONAL FUND ADVISORS LP | 109.3K | $2.17M | $124.1K | Added$1.48M |
| Walleye Capital LLC | 108K | $2.15M | — | New |
| BURKEHILL GLOBAL MANAGEMENT, LP | 100K | $1.99M | — | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 90.3K | $1.8M | $333.9K | Added$194.2K |
| TWO SIGMA INVESTMENTS, LP | 89.9K | $1.79M | $275K | Added$130.3K |
| Bank of New York Mellon Corp | 83.3K | $1.66M | $254.8K | Added$163.7K |
| Shay Capital LLC | 63.5K | $1.26M | $194.3K | Added$180.8K |
| SEVEN GRAND MANAGERS, LLC | 62.5K | $1.24M | — | New |
| MARTINGALE ASSET MANAGEMENT L P | 57.5K | $1.14M | — | New |
| Mariner, LLC | 55K | $1.09M | $168.3K | Added$8.02K |
| Swiss National Bank | 55K | $1.09M | $98.8K | Added$550.3K |
| SCS Capital Management LLC | 53.4K | $1.06M | $163.5K | Added$163.5K |
| ALPS ADVISORS INC | 51.6K | $1.03M | $137.6K | Added$268.9K |
| AMERICAN CENTURY COMPANIES INC | 51.6K | $1.03M | $74.9K | Added$613.2K |
| Swiss Life Asset Management Ltd | 8.65K | $978.7K | — | New |
| Nuveen, LLC | 44K | $874.8K | $118.9K | Added$221.1K |
| RHUMBLINE ADVISERS | 40.7K | $810.5K | $124.2K | Added$127.4K |
| BNP PARIBAS FINANCIAL MARKETS | 40.4K | $803.5K | $123.6K | Cut−$810.5K |
| Rafferty Asset Management, LLC | 38K | $755.9K | $116.3K | Cut−$250.9K |
| Invesco Ltd. | 31.6K | $629.5K | $64.3K | Added$276K |
| Bleakley Financial Group, LLC | 29.3K | $583.4K | $89.3K | Added$92.3K |
| BARCLAYS PLC | 28.8K | $573.3K | $88.2K | Cut−$1.16M |
| PRUDENTIAL FINANCIAL INC | 27.3K | $543.6K | — | New |
| ALLIANCEBERNSTEIN L.P. | 31.8K | $535.7K | $0 | Added$45.8K |
| Optimize Financial Inc | 24K | $477.3K | — | New |
| VANGUARD ASSET MANAGEMENT, Ltd | 23.9K | $476.2K | — | Held |
| Caption Management, LLC | 23K | $457.5K | $70.4K | Added$70.4K |
| Legal & General Group Plc | 22.2K | $442.1K | $48.8K | Added$173.5K |
| Creative Planning | 21.8K | $433.9K | $66.8K | Added$66.5K |
| Balyasny Asset Management L.P. | 21.8K | $433.5K | — | New |
| Russell Investments Group, Ltd. | 19.9K | $395.7K | $60.9K | Cut−$556.9K |
| MetLife Investment Management, LLC | 18.4K | $365.2K | $56.2K | Added$3.02K |
| VOYA INVESTMENT MANAGEMENT LLC | 18K | $358.2K | $55.1K | Added$52K |
| Quantinno Capital Management LP | 17.6K | $350.3K | $46.4K | Added$95.1K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17.7K | $349.1K | $54.2K | Added$46.3K |
| PROFUND ADVISORS LLC | 17.1K | $340.7K | $52.4K | Cut−$32.6K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 16.9K | $336.6K | $51.8K | Added$47.8K |
| AMERIPRISE FINANCIAL INC | 15.8K | $314.6K | $48.4K | Added$44.8K |
| WELLS FARGO & COMPANY/MN | 15K | $297.9K | $45.8K | Cut−$295.2K |
| Virtus Investment Advisers, LLC | 14.8K | $293.5K | $44K | Added$51.2K |
| Ascent Group, LLC | 14.2K | $281.5K | $43.3K | Added$43.3K |
| LPL Financial LLC | 14.1K | $280.6K | $43.2K | Added$40.2K |
| Susquehanna Portfolio Strategies, LLC | 14K | $278.8K | — | New |
| ADAR1 Capital Management, LLC | 13.7K | $272.6K | $41.9K | Added$41.9K |
| VARCOV Co. | 13.3K | $264.4K | $40.7K | Added$938 |
| Icahn Capital | 13.2K | $262.3K | — | New |
| Vanguard Global Advisers, LLC | 12.7K | $253.3K | — | Held |
| China Universal Asset Management Co., Ltd. | 11.2K | $223.6K | $27.3K | Added$73.4K |
| LETKO, BROSSEAU & ASSOCIATES INC | 11.2K | $222.3K | $34.2K | Added$34.2K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10.9K | $217.7K | $33.5K | Cut−$298.9K |
| Squarepoint Ops LLC | 10.8K | $214.2K | — | New |
| Thrive Wealth Management, LLC | 10.3K | $205.7K | — | New |
| VICTORY CAPITAL MANAGEMENT INC | 10.1K | $200.3K | $30.8K | Added$30.8K |
| Police & Firemen's Retirement System of New Jersey | 9.84K | $195.6K | $30.1K | Added$30.1K |
| CITIGROUP INC | 9.59K | $190.6K | $29.3K | Cut−$931.9K |
| NEW YORK STATE COMMON RETIREMENT FUND | 7.5K | $149.2K | $23K | Added$22.9K |
| Vanguard Investments Australia, Ltd. | 7.43K | $147.7K | — | Held |
| T. Rowe Price Investment Management, Inc. | 6.61M | $131.4K | $9.9K | Added$76.9K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 6.4K | $127.3K | — | New |
| KLP KAPITALFORVALTNING AS | 6.1K | $121.3K | $10.7K | Added$62.4K |
| OSAIC HOLDINGS, INC. | 4.49K | $89.3K | $13.7K | Added$13.7K |
| Larson Financial Group LLC | 3.5K | $69.5K | $10.7K | Added$9.62K |
| Mirae Asset Global Investments Co., Ltd. | 3.31K | $65.7K | $8.15K | Added$20.9K |
| Ameritas Investment Partners, Inc. | 2.89K | $57.5K | $8.85K | Added$8.85K |
| Caitong International Asset Management Co., Ltd | 2.54K | $50.6K | $7.78K | Cut−$46.6K |
| Tower Research Capital LLC (TRC) | 2.46K | $49K | $2.09K | Added$37.5K |
| GAMMA Investing LLC | 1.4K | $27.8K | $3.44K | Added$8.91K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.38M | $27.4K | $4.21K | Added$1.13K |
| GROUP ONE TRADING LLC | 1.31K | $26K | $4K | Cut−$258.7K |
| GF FUND MANAGEMENT CO. LTD. | 1.22K | $24.3K | $3.29K | Added$6.16K |
| CWM, LLC | 1.14K | $22.6K | $22.6K | Added$22.6K |
| Sterling Capital Management LLC | 1K | $19.9K | $3.06K | Cut−$9.06K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 610 | $12.1K | $233 | Added$10.9K |
| Rockefeller Capital Management L.P. | 601 | $12K | $371 | Added$9.92K |
| Western Wealth Management, LLC | 530 | $10.5K | — | New |
| Versant Capital Management, Inc | 434 | $8.63K | $330 | Added$6.81K |
| PNC Financial Services Group, Inc. | 383 | $7.62K | $977 | Added$2.25K |
| ALGERT GLOBAL LLC | 330.8K | $6.58K | $974 | Added$1.22K |
| EverSource Wealth Advisors, LLC | 315 | $6.27K | $946 | Added$1.06K |
| US BANCORP \DE\ | 251 | $4.99K | $716 | Added$1.05K |
| Smartleaf Asset Management LLC | 248 | $4.72K | $724 | Added$305 |
| PRIVATE TRUST CO NA | 225 | $4.47K | $688 | Added$688 |
| JONES FINANCIAL COMPANIES LLLP | 229 | $4.21K | — | New |
| FIFTH THIRD BANCORP | 170 | $3.38K | — | New |
| NISA INVESTMENT ADVISORS, LLC | 161 | $3.2K | $492 | Cut−$6.39K |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 157 | $3.12K | — | New |
| Rossby Financial, LCC | 111 | $2.28K | — | New |
| ROYAL BANK OF CANADA | 80 | $2K | $669 | Cut−$16K |
| Farther Finance Advisors, LLC | 80 | $1.64K | $245 | Added$512 |
| Allworth Financial LP | 74 | $1.47K | $162 | Added$580 |
| MAI Capital Management | 57 | $1.13K | $137 | Added$376 |
| HRT FINANCIAL LP | 40.2K | $799 | $123 | Cut−$44 |
| Parallel Advisors, LLC | 36 | $716 | — | New |
| CoreCap Advisors, LLC | 32 | $636 | $97 | Added$97 |
| ROTHSCHILD INVESTMENT LLC | 30 | $597 | — | New |
| Root Financial Partners, LLC | 29 | $577 | — | New |
| WPG Advisers, LLC | 28 | $557 | $79 | Added$119 |
| True Wealth Design, LLC | 23 | $458 | $70 | Added$70 |
| QUADRANT CAPITAL GROUP LLC | 13 | $259 | — | New |
| Stone House Investment Management, LLC | 11 | $219 | $31 | Added$51 |
| Essential Partners LLC | 9 | $179 | $28 | Added$28 |
| Arax Advisory Partners | 8 | $159 | $10 | Added$109 |